Make your casino vacation a sure bet with Expedia and. . Browse our selection of 4 Casino hotels & resorts in Naples, FL for the ultimate stay & play vacation. The Seminole Casino Hotel is Southwest Florida's top destination for slots and live blackjack. With an array of slot machines and live table games, there are. But no need to worry, there are some fantastic surrounding casinos, particularly Bonita Springs Napoli Fort Myers Casino, Seminole Casino Hotel Immokalee.